Publications

2017

Murugan M, Jang HJ, Park M, Miller E, Taliaferro J, Cox J, Parker NF, Bhave V, Nectow A, Pillow J, Witten IB. Combined social and spatial coding in a descending projection from prefrontal cortex. bioRxiv doi.org/10.1101/155929, in press at Cell.

Uematsu A, Tan B, Sulkes J, Ycu E, Junyent F, Koivumaa J, Kremer E, Witten IB, Deisseroth K, Johansen J. Modular Organization of the Brainstem Noradrenaline System Coordinates Opposing Learning States. Nature Neuroscience. Sept 2017.

2016

Akhlaghpour H, Wiskerke J,  Choi JY, Taliaferro JP, Au J, Witten IB. Dissociated sequential activity and stimulus encoding in the dorsomedial striatum during spatial working memory. eLife. 2016; 10.7554/eLife.19507.

Lee J*, Finkelstein J*, Choi JY, Witten IB. Linking cholinergic interneurons, synaptic plasticity, and behavior during the extinction of a cocaine-context association. Neuron. 2016. Jun 1;90(5):1071-85. doi: 10.1016/j.neuron.2016.05.001. [comment by Rossi & Stuber]

Parker NF, Cameron CM, Taliaferro JP, Lee J, Choi JY, Davidson TJ, Daw ND, Witten IB. Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target. Nature Neuroscience. 2016 April 25. doi: 10.1038/nn.4287. [recommendation in F1000]

Bak JH, Choi JY, Akrami A, Witten IB, Pillow J. Adaptive optimal training of animal behavior. Neural Information Processing Systems. 2016. 1947-1955.

Parker NF, Witten IB. Gaining on reward prediction errors. Nature Neuroscience. 23 Feb 2016. 19: 418-419. doi:10.1038/nn.4246. [comment on Eshel et al.]

Dautan D, Souza AS, Huerta-Ocampo I, Valencia M, Assous M, Witten IB, Deisseroth K, Tepper JM, Bolam JP, Gerdjikov TV, Mena-Segovia J. Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits. Nature Neuroscience.  Jun 27 2016. doi: 10.1038/nn.4335.

Ye L, Allen WE, Thompson KR, Tian Q, Hsueh B, Ramakrishnan C, Wang AC, Jennings JH, Adhikari A, Halpern CH, Witten IB, Barth AL, Luo L, McNab JA, Deisseroth K. Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct ExperiencesCell. 2016 May 25. doi: 10.1016/j.cell.2016.05.010.

Decot HK, Namboodiri VM, Gao W, McHenry JA, Jennings JH, Lee SH, Kantak PA, Jill Kao YC, Das M, Witten IB, Deisseroth K, Shih YI, Stuber GD. Coordination of brainwide activity by dopamine neurons.  Neuropsychopharmacology. 2016 Sep 14. doi: 10.1038/npp.2016.151.

2015

Saddoris MP, Sugam JA, Stuber GD, Witten IB, Deisseroth K, Carelli RM. Mesolimbic dopamine dynamically tracks, and is causally linked to, discrete aspects of value-based decision making.  Biol Psychiatry. 2015 May 15;77(10):903-11. doi: 10.1016/j.biopsych.2014.10.024. Epub 2014 Nov 13.

2014

McCutcheon JE, Cone JJ, Sinon CG, Fortin SM, Kantak PA, Witten IB, Deisseroth K, Stuber GD, Roitman MF.Optical suppression of drug-evoked phasic dopamine release. Front Neural Circuits. 2014 Sep 17;8:114. doi: 10.3389/fncir.2014.00114. eCollection 2014.

Steinberg EE, Boivin JR, Saunders BT, Witten IB, Deisseroth K, Janak PH. Positive reinforcement mediated by midbrain dopamine neurons requires d1 and d2 receptor activation in the nucleus accumbens.  PLoS One. 2014 Apr 14;9(4):e94771. doi: 10.1371/journal.pone.0094771.

Dautan D, Huerta-Ocampo I, Witten IB, Deisseroth K, Bolam JP, Gerdjikov T, Mena-Segovia J.  A major external source of cholinergic innervation of the striatum and nucleus accubmens orginates in the brainstem. J Neurosci. 2014 Mar 26;34(13):4509-18. doi: 10.1523/JNEUROSCI.5071-13.2014.

2013

Steinberg EE*, Keiflin R*, Boivin JR, Witten IB, Deisseroth K, Janak PH. A causal link between prediction errors, dopamine neurons and learning. Nature Neuroscience. 2013 May 26. doi: 10.1038/nn.3413.

DePuy SD, Stornetta RL, Bochorishvili G, Deisseroth K, Witten IB, Coates M, Guyenet PG. Glutamatergic neurotransmission between the C1 neurons and the parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus. J Neurosci. 2013 Jan 23;33(4):1486-97.

2012

Tye KM*, Mirzabekov JJ*, Warden MR*, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. Dopamine neurons modulate neural encoding and expression of depression-related behavior. Nature. 2012 Dec 12. doi: 10.1038/nature11740.

2011

Witten IB*, Steinberg E*, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye K, Janak P, Deisseroth K. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcementNeuron. 2011 Dec 8. 72(5): 721-33.

Anikeeva P*, Andalman AS*, Witten IB, Warden MR, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K. Optetrode: a multichannel readout for optogenetic control in freely moving miceNature Neuroscience. 2011 Dec 4. doi: 10.1038/nn.2992.

2010

Witten IB* Lin SC*, Brodsky M*, Prakash R*, Diester I, Anikeeva P, Gradinaru V, Ramakrishnan C, Deisseroth, K. Cholinergic interneurons control local circuit activity and cocaine conditioning. Science. 2010 Dec 17. 330(6011), 1677-81.

Witten IB, Knudsen PF, Knudsen EI. A dominance hierarchy of auditory spatial cues in barn owls. PLoS One. 2010 Apr 28;5(4):e10396. doi: 10.1371/journal.pone.0010396.

Before 2009

Witten IB, Knudsen EI, Sompolinsky H. A Hebbian learning rule mediates asymmetric plasticity in aligning sensory representations.J Neurophysiol. 2008 Aug;100(2):1067-79. doi: 10.1152/jn.00013.2008.

Witten IB*, Bergan JF*, Knudsen EI. Dynamic shifts in the owl’s auditory space map predict moving sound location.Nat Neurosci. 2006 Nov;9(11):1439-45.

Witten IB, Knudsen EI. Why seeing is believing: merging auditory and visual worlds.Neuron. 2005 Nov 3;48(3):489-96. Review.

 

 

*: equal authorship contribution