Publications

Preprints

Pan Vazquez A*, Sanchez Araujo Y*, McMannon B, Louka M, Bandi A, Haetzel L, International Brain Laboratory, Pillow JW,  Daw ND, Witten IB. Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories. bioRxiv. 2024.

Sagiv Y, Akam T, Witten IB, Daw ND, Prioritizing replay when future goals are unknown. bioRxiv. 2024.

Zhukovskaya A, Zimmerman CA, Willmore L, Janarthanan SN, Falkner AL, Witten IB. Differences in an aversive teaching signal produce brainwide and behavioral substrates of susceptibility. bioRxiv. 2023.

Zimmerman CA, Pan-Vazquez A, Wu B, Keppler EF, Guthman EM, Fetcho RN, Bolkan SS, McMannon B, Lee J, Hoag AT, Lynch LA, Janarthanan SN, López Luna JF, Bondy AG, Falkner AL, Wang SSH, Witten IB. A neural mechanism for learning from delayed postingestive feedback. bioRxiv. 2023.

Brown LS, Cho J, Bolkan SS, Nieh EH, Schottdorf M, Tank DW, Brody C, Witten IB#, Goldman MS#. Neural circuit models for evidence accumulation through choice-selective sequences. bioRxiv 2023.

The International Brain Laboratory, et al. A brainwide map of neural activity during mouse decision-making. bioRxiv. 2023.

Finding, et al. Brainwide representations of prior information in mouse decision-making. bioRxiv. 2023.

The International Brain Laboratory, et al. Reproducibility of in-vivo electrophysiological measurements in mice. bioRxiv. 2022.

2024

Lee RS, Sagiv Y, Engelhard B,  Witten IB#, Daw ND#. A feature-specific reward prediction error model explains dopaminergic heterogeneity. Nature Neuroscience. In press. bioRxiv. 2022.

Minakuchi T, Guthman E, Acharya P, Hinson J, Fleming W, Witten IB, Oline SN, Falkner AL. Independent inhibitory control mechanisms for aggressive motivation and action. Nature Neuroscience. Jan 2024. bioRxiv. 2022.

2023

Willmore L*, Minerva A*, Engelhard B*#, McMannon B, Oak N, Thiberge S, Murugan M, Pena CJ#, Witten IB#. Overlapping representations of food and social stimuli in VTA dopamine neurons. Neuron. bioRxiv. 2023. 

Cox J#, Minerva AR, Fleming WT,  Zimmerman CA, Hayes C, Zorowitz S, Bandi A, Ornelas S, McMannon B,  Parker NF, Witten IB#. A neural substrate of sex-dependent modulation of motivation by value. Nature Neuroscience. Jan 2023. bioRxiv 2022.

2022

Willmore L, Cameron C, Yang J, Witten IB#, Falkner A#. Behavioral and dopaminergic signatures of resilience. Nature. Oct 2022. bioRxiv 2022.

Fleming W, Lee J, Briones BA, Bolkan SS, Witten IB, Cholinergic interneurons mediate cocaine extinction through plasticity across medium spiny neuron subtypes. Cell Reports. May 2022. bioRxiv 2021.

Parker NF*, Baidya A*, Cox J*, Haetzel L, Murugan M, Engelhard B, Zhukovskaya A, Goldman MS#, Witten IB#. Choice-selective sequences dominate in cortical relative to thalamic inputs to the NAc to support reinforcement learning.  Cell Reports. May 2022. bioRxiv 2021.

Bolkan SS*, Stone IR*, Pinto L, Ashwood ZC, Garcia J, Herman AL, Singh P, Bandi A, Cox J, Zimmerman CA, Cho J, Engelhard B, Koay SA, Pillow JW, Witten IB. Strong and opponent contributions of dorsomedial striatal pathways to behavior depends on cognitive demands and task strategy. Nature Neuroscience. Mar 2022. bioRxiv 2021.

2021

Briones BA, Pitcher MN,  Fleming WT, Libby A, Diethorn EJ, Haye AE, MacDowell CJ,  Zych AD, Waters RC, Buschman TJ,  Witten IB, Gould E. Perineuronal nets in the dorsomedial striatum contribute to behavioral dysfunction in mouse models of excessive repetitive behavior. Biological Psychiatry Global Open Science. Nov 2021.

Fleming W*, Jewell S*, Engelhard B, Witten DM#, Witten IB#. Inferring spikes from calcium imaging in dopamine neurons. Plos One. May 2021. bioRxiv 2020.

The International Brain Laboratory, et al. Standardized and reproducible measurement of decision-making in mice. eLife. May 2021. bioRxiv 2020.

2020

Choi JY, Jang HJ, Ornelas S, Fleming W, Furth D, Au J, Bandi A, Engel E, Witten IB. A comparison of dopaminergic and cholinergic populations reveals unique contributions of VTA dopamine neurons to short-term memory. Cell Reports. Dec 2020. bioRxiv 2020.

Cai LX, Pizano K, Gundersen G, Hayes C, Fleming W, Cox J, Witten IB. Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times. eLife. June 2020. bioRxiv 2020.

2019

Cox J, Witten IB. Striatal circuits for reward learning and decision making. Nature Reviews Neuroscience. June 2019. 

Engelhard B, Finkelstein J, Cox J, Fleming W, Jang H, Ornelas S, Koay S, Thiberge S, Daw N, Tank D, Witten IB. Specialized and spatially organized coding of sensory, motor, and cognitive variables in midbrain dopamine neurons. Nature. May 2019. bioRxiv 2018.

Cameron C, Murugan M, Choi JY, Engel E, Witten IB.  Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons. Neuron. May 2019.

Lee R, Mattar M, Parker NF, Witten IB#, Daw N#. Reward prediction error does not explain movement selectivity in DMS-projecting DA neurons. eLife. April 2019. bioRxiv 2019.

Lohani S, Martig A, Deisseroth K, Witten IB, Moghaddam B. Dopamine Modulation of Prefrontal Cortex Activity Is Manifold and Operates at Multiple Temporal and Spatial Scales. Cell Reports. April 2019. bioRxiv 2018.

2018

Pinto L, Koay SA, Engelahrd B, Yoon AM, Deverett B, Thiberge SY, Witten IB, Tank DW, Brody CD. An Accumulation-of-Evidence Task Using Visual Pulses for Mice Navigating in Virtual Reality. Front Behav Neuro. Mar 2018. bioRxiv 2018.

2017

Murugan M, Jang HJ, Park M, Miller E, Taliaferro J, Cox J, Parker NF, Bhave V, Nectow A, Pillow J, Witten IB. Combined social and spatial coding in a descending projection from the prefrontal cortex.  Cell. Dec 2017. bioRxiv 2017.

The International Brain Laboratory. An international laboratory for systems and computational neuroscience. Neuron. Dec 2017.

Uematsu A, Tan B, Sulkes J, Ycu E, Junyent F, Koivumaa J, Kremer E, Witten IB, Deisseroth K, Johansen J. Modular Organization of the Brainstem Noradrenaline System Coordinates Opposing Learning States. Nature Neuroscience. Sept 2017.

2016

Akhlaghpour H, Wiskerke J,  Choi JY, Taliaferro JP, Au J, Witten IB. Dissociated sequential activity and stimulus encoding in the dorsomedial striatum during spatial working memory. eLife. 2016; 10.7554/eLife.19507.

Lee J*, Finkelstein J*, Choi JY, Witten IB. Linking cholinergic interneurons, synaptic plasticity, and behavior during the extinction of a cocaine-context association. Neuron. 2016. Jun 1;90(5):1071-85. doi: 10.1016/j.neuron.2016.05.001. [comment by Rossi & Stuber]

Parker NF, Cameron CM, Taliaferro JP, Lee J, Choi JY, Davidson TJ, Daw ND, Witten IB. Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target. Nature Neuroscience. 2016 April 25. doi: 10.1038/nn.4287. [recommendation in F1000]

Bak JH, Choi JY, Akrami A, Witten IB, Pillow J. Adaptive optimal training of animal behavior. Neural Information Processing Systems. 2016. 1947-1955.

Parker NF, Witten IB. Gaining on reward prediction errors. Nature Neuroscience. Feb 2016. [comment on Eshel et al.]

Dautan D, Souza AS, Huerta-Ocampo I, Valencia M, Assous M, Witten IB, Deisseroth K, Tepper JM, Bolam JP, Gerdjikov TV, Mena-Segovia J. Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits. Nature Neuroscience.  Jun 2016.

Ye L, Allen WE, Thompson KR, Tian Q, Hsueh B, Ramakrishnan C, Wang AC, Jennings JH, Adhikari A, Halpern CH, Witten IB, Barth AL, Luo L, McNab JA, Deisseroth K. Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences. Cell. May 2016.

Decot HK, Namboodiri VM, Gao W, McHenry JA, Jennings JH, Lee SH, Kantak PA, Jill Kao YC, Das M, Witten IB, Deisseroth K, Shih YI, Stuber GD. Coordination of brainwide activity by dopamine neurons.  Neuropsychopharmacology. Sept 2016.

2015

Saddoris MP, Sugam JA, Stuber GD, Witten IB, Deisseroth K, Carelli RM. Mesolimbic dopamine dynamically tracks, and is causally linked to, discrete aspects of value-based decision making.  Biol Psychiatry. May 2015.

2014

McCutcheon JE, Cone JJ, Sinon CG, Fortin SM, Kantak PA, Witten IB, Deisseroth K, Stuber GD, Roitman MF. Optical suppression of drug-evoked phasic dopamine release. Front Neural Circuits. Sep 2014.

Steinberg EE, Boivin JR, Saunders BT, Witten IB, Deisseroth K, Janak PH. Positive reinforcement mediated by midbrain dopamine neurons requires d1 and d2 receptor activation in the nucleus accumbens.  PLoS One. Apr 2014.

Dautan D, Huerta-Ocampo I, Witten IB, Deisseroth K, Bolam JP, Gerdjikov T, Mena-Segovia J.  A major external source of cholinergic innervation of the striatum and nucleus accubmens orginates in the brainstem. J Neurosci. Mar 2014.

2013

Steinberg EE*, Keiflin R*, Boivin JR, Witten IB, Deisseroth K, Janak PH. A causal link between prediction errors, dopamine neurons and learning. Nature Neuroscience. 2013 May 26. doi: 10.1038/nn.3413.

DePuy SD, Stornetta RL, Bochorishvili G, Deisseroth K, Witten IB, Coates M, Guyenet PG. Glutamatergic neurotransmission between the C1 neurons and the parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus. J Neurosci. 2013 Jan 23;33(4):1486-97.

2012

Tye KM*, Mirzabekov JJ*, Warden MR*, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. Dopamine neurons modulate neural encoding and expression of depression-related behavior. Nature. 2012 Dec 12. doi: 10.1038/nature11740.

2011

Witten IB*#, Steinberg E*, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye K, Janak P#, Deisseroth K#. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 2011 Dec 8. 72(5): 721-33.

Anikeeva P*, Andalman AS*, Witten IB, Warden MR, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K. Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nature Neuroscience. 2011 Dec 4. doi: 10.1038/nn.2992.

2010

Witten IB* Lin SC*, Brodsky M*, Prakash R*, Diester I, Anikeeva P, Gradinaru V, Ramakrishnan C, Deisseroth, K. Cholinergic interneurons control local circuit activity and cocaine conditioning. Science. 2010 Dec 17. 330(6011), 1677-81.

Witten IB, Knudsen PF, Knudsen EI. A dominance hierarchy of auditory spatial cues in barn owls. PLoS One. 2010 Apr 28;5(4):e10396. doi: 10.1371/journal.pone.0010396.

Before 2009

Witten IB, Knudsen EI, Sompolinsky H. A Hebbian learning rule mediates asymmetric plasticity in aligning sensory representations. J Neurophysiol. 2008 Aug;100(2):1067-79. doi: 10.1152/jn.00013.2008.

Witten IB*, Bergan JF*, Knudsen EI. Dynamic shifts in the owl’s auditory space map predict moving sound location. Nature Neuroscience. 2006 Nov;9(11):1439-45.

Witten IB, Knudsen EI. Why seeing is believing: merging auditory and visual worlds. Neuron. 2005 Nov 3;48(3):489-96. Review.